Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

In vivo, the interior and exterior of cells is populated by various macromolecules that create
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …

Stem cells are unspecialized cells that have the potential for self-renewal and differentiation
into more specialized cell types. The chemical and physical properties of surrounding …

Scaffolds for tissue engineering aim to mimic the native extracellular matrix (ECM) that
provides physical support and biochemical signals to modulate multiple cell behaviors …

Abstract Development of mesenchymal stem cell-based tissue engineered implantable
devices requires prolonged in vitro culture for the development of a three-dimensional …

In multicellular organisms, the intracellular and extracellular spaces are considerably
packed with a diverse range of macromolecular species. Yet, standard eukaryotic cell …

Extracellular matrix proteins are associated with metabolically healthy adipose tissue and
regulate inflammation, fibrosis, angiogenesis, and subsequent metabolic deterioration. In …

Scaffold-free in vitro organogenesis exploits the innate ability of cells to synthesise and
deposit their own extracellular matrix to fabricate tissue-like assemblies. Unfortunately, cell …

Collagen I is the primary extracellular matrix component of most solid tumors and influences
metastatic progression. Collagen matrix engineering techniques are useful for …