The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular
volume homeostasis and blood pressure through complex mechanisms. Apart from the well …

Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of
acid-base homeostasis. However, in recent years the understanding of the function of the …

Abstract The (pro) renin receptor ((P) RR) was first identified as a single-transmembrane
receptor in human kidneys and initially attracted attention owing to its potential role as a …

The increased activity of intrarenal renin–angiotensin system (RAS) in a setting of elevated
arterial pressure elicits renal vasoconstriction, increased sodium reabsorption, proliferation …

The intrarenal renin–angiotensin system is critical for the regulation of tubule sodium
reabsorption, renal haemodynamics and blood pressure. The excretion of renin in urine can …

The extracellular domain of the (pro) renin receptor [(P) RR] is cleaved to generate the
soluble form of (P) RR [s (P) RR]. Multiple clinical studies have revealed the association …

Cardiovascular disease is a pathology that exhibits well-researched biological sex
differences, making it possible for physicians to tailor preventative and therapeutic …

Excessive proteinuria leads to renal dysfunction and damage. Ganoderma lucidum
polysaccharide peptide (GL-PP) and Ganoderma lucidum polysaccharide peptide 2 (GL …

A high-fructose diet is shown to induce salt-sensitive hypertension, but the underlying
mechanism largely remains unknown. The major goal of the present study was to test the …

Rationale: Cleavage of the extracellular domain of the PRR ([pro] renin receptor) yields a
soluble fragment (sPRR). Although changes in plasma sPRR levels have been reported in …