Introduction: the spectrum of pulmonary complications in sickle cell anemia (SCA) comprises
mainly of acute chest syndrome (ACS), pulmonary hypertension (PH) and Airway hyper …

Hypoxemia is common in SCD and likely exacerbates SCD vasculopathy. Pulse oximeter
correlation with arterial oxygen tension in patients with SCD may at times be poor and …

Rationale: Pulmonary complications of sickle cell anemia (Hb-SS) commonly cause
morbidity, yet few large studies of pulmonary function tests (PFTs) in this population have …

Background: Pulmonary complications are a major cause of morbidity and mortality in sickle
cell disease (SCD). The relationship of asthma with SCD and acute chest syndrome (ACS) …

Rationale: Sickle cell disease (SCD) results in significant morbidity and mortality attributable
to pulmonary complications. The pattern of lung function change across childhood in SCD is …

Median life expectancy of patients with sickle cell disease has increased to up to 55 years
but there are still frequent cases of premature death, mostly in patients with pre-existing …

Pulmonary hypertension (PHT) develops in sickle cell disease (SCD) and is associated with
high mortality. We previously showed that erythroid cells produce placenta growth factor …

Objectives To prospectively assess longitudinal lung function in children with sickle cell
disease (SCD). Working hypothesis Lung function in SCD children deteriorates with …

The aim of this study was to assess the impact of recurrent acute chest syndrome (ACS)
episodes on the lung function of young adults with sickle cell disease (SCD). Our …

Rationale: Patient factors associated with development of abnormal lung function in children
with sickle cell anemia (SCA) have not been fully characterized. Objectives: To characterize …