Tertiary lymphoid structures: autoimmunity goes local

E Pipi, S Nayar, DH Gardner, S Colafrancesco… - Frontiers in …, 2018 - frontiersin.org
Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune
diseases. TLS present features of secondary lymphoid organs such as segregated T and B …

Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for rheumatoid arthritis

Q Luo, L Zhang, X Li, B Fu, Z Deng… - Clinical & …, 2018 - academic.oup.com
Circular RNAs (circRNAs) are a new class of RNAs that can be used as biomarkers in
clinical blood samples. However, little is known about circRNAs' diagnostic values for …

At critically low antigen densities, IgM hexamers outcompete both IgM pentamers and IgG1 for human complement deposition and complement-dependent cytotoxicity

N Oskam, P Ooijevaar-de Heer… - The Journal of …, 2022 - journals.aai.org
IgM is secreted as a pentameric polymer containing a peptide called the joining chain (J
chain). However, integration of the J chain is not required for IgM assembly and in its …

Rheumatoid factor autoantibody repertoire profiling reveals distinct binding epitopes in health and autoimmunity

N Oskam, P Ooijevaar-De Heer, D Kos… - Annals of the …, 2023 - ard.bmj.com
Background Rheumatoid factors (RF) are one of the hallmark autoantibodies characteristic
of rheumatoid arthritis (RA), and are frequently observed in other diseases and in healthy …

Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New‐Onset Rheumatoid Arthritis

Q Luo, J Liu, B Fu, L Zhang, Y Guo, Z Huang… - Disease …, 2019 - Wiley Online Library
This study is aimed at exploring the levels of peripheral blood circular RNAs (circRNAs) as
biomarker candidates for the diagnosis of new‐onset rheumatoid arthritis (RA). The selected …

Abberant immunoglobulin G glycosylation in rheumatoid arthritis by LTQ-ESI-MS

Z Su, Q Xie, Y Wang, Y Li - International journal of molecular sciences, 2020 - mdpi.com
Aberrant glycosylation has been observed in many autoimmune diseases. For example,
aberrant glycosylation of immunoglobulin G (IgG) has been implicated in rheumatoid arthritis …

Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

Q Luo, X Li, L Zhang, F Yao… - Molecular …, 2019 - spandidos-publications.com
Abstract Peptidoglycan recognition protein‑1 (PGLYRP‑1) is a part of the innate immune
system. It is well‑known that dysregulation of innate immune responses is present in patients …

Clinically relevant discrepancies between different rheumatoid factor assays

WJJ Falkenburg, HJ Von Richthofen… - Clinical Chemistry and …, 2018 - degruyter.com
Background: Accurate measurements of rheumatoid factors (RFs), autoantibodies binding
IgG, are important for diagnosing rheumatoid arthritis (RA) and for predicting disease …

Identification of clinically and pathophysiologically relevant rheumatoid factor epitopes by engineered IgG targets

WJJ Falkenburg, N Oskam, J Koers… - Arthritis & …, 2020 - Wiley Online Library
Objective Rheumatoid factors (RFs), which are anti‐IgG autoantibodies strongly associated
with rheumatoid arthritis (RA), are also found in other diseases and in healthy individuals …

On the origin of rheumatoid factors: Insights from analyses of variable region sequences

WJJ Falkenburg, HJ von Richthofen… - Seminars in arthritis and …, 2019 - Elsevier
Abstract Objectives Rheumatoid factors (RFs) are thought to play an important role in
rheumatoid arthritis (RA), but are also found in healthy donors (HDs). Previous studies …