The complicated lives of GPCRs in cardiac fibroblasts
GR Mazarura, JCC Dallagnol… - … of Physiology-Cell …, 2022 - journals.physiology.org
The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system is
well understood in cardiomyocytes and vascular smooth muscle cells (VSMCs). In the …
well understood in cardiomyocytes and vascular smooth muscle cells (VSMCs). In the …
Combination of docking-based and pharmacophore-based virtual screening identifies novel agonists that target the urotensin receptor
N Li, L Yin, X Chen, J Shang, M Liang, L Gao, G Qiang… - Molecules, 2022 - mdpi.com
The urotensin receptor (UT receptor), a G-protein-coupled receptor mediating urotensin-II
and urotensin-II-related peptide signaling in the urotensinergic system, has multiple …
and urotensin-II-related peptide signaling in the urotensinergic system, has multiple …
Expanding Structure–Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key Role of the N-Terminal Region for Novel Urotensin II Receptor …
F Merlino, A Secondo, E Mitidieri… - Journal of Medicinal …, 2024 - ACS Publications
While the urotensinergic system plays a role in influencing various pathologies, its potential
remains untapped because of the absence of therapeutically effective urotensin II receptor …
remains untapped because of the absence of therapeutically effective urotensin II receptor …
Disulfide Bond Replacement with 1, 4‐and 1, 5‐Disubstituted [1, 2, 3]‐Triazole on C‐X‐C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that …
Here we investigated the structural and biological effects ensuing from the disulfide bond
replacement of a potent and selective C‐X‐C chemokine receptor type 4 (CXCR4) peptide …
replacement of a potent and selective C‐X‐C chemokine receptor type 4 (CXCR4) peptide …
Exploration of the urocontrin A scaffold yields new urotensinergic system allosteric modulator and competitive antagonists
E Billard, TE Hébert, D Chatenet - Biochemical Pharmacology, 2023 - Elsevier
The urotensinergic system, involved in the development and/or progression of numerous
pathological conditions, is composed of one G protein-coupled receptor (UT) and two …
pathological conditions, is composed of one G protein-coupled receptor (UT) and two …
Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands
H Nassour, TA Hoang, RD Martin… - Journal of Biological …, 2021 - ASBMB
Over the last decade, the urotensinergic system, composed of one G protein-coupled
receptor and two endogenous ligands, has garnered significant attention as a promising …
receptor and two endogenous ligands, has garnered significant attention as a promising …
Insights into the Molecular Determinants Involved in Urocontrin and Urocontrin A Action
E Billard, D Chatenet - ACS Medicinal Chemistry Letters, 2020 - ACS Publications
In the past few years, we have identified two allosteric modulators of the urotensinergic
system with probe-dependent action, termed Urocontrin (UC) and Urocontrin A (UCA). Such …
system with probe-dependent action, termed Urocontrin (UC) and Urocontrin A (UCA). Such …
Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors
Despite the observation of synergistic interactions between the urotensinergic and
angiotensinergic systems, the interplay between the urotensin II receptor (hUT) and the …
angiotensinergic systems, the interplay between the urotensin II receptor (hUT) and the …
Determination of Urotensin Ii Levels Before and After Lsg in Patients With Obesity
D Binnetoglu, K Binnetoglu, M Yayla - 2023 - researchsquare.com
Purpose The goal of this study is to measure and compare the levels of UII in adipose tissue
and serum in obese and non-obese individuals. Methods This study is to measure and …
and serum in obese and non-obese individuals. Methods This study is to measure and …
The complicated lives of GPCRs in cardiac fibroblasts
E Hébert - journals.physiology.org
The complicated lives of GPCRs in cardiac fibroblasts Grace R. Mazarura1, Juliana CC
Dallagnol1,2,3, David Chatenet2, Bruce. G Page 1 1 The complicated lives of GPCRs in cardiac …
Dallagnol1,2,3, David Chatenet2, Bruce. G Page 1 1 The complicated lives of GPCRs in cardiac …