The endocannabinoid (eCB) system is one the most ubiquitous signaling systems of the
brain and offers a rich pharmacology including multiple druggable targets. Preclinical …

Cannabinoids are a promising method for pharmacological treatment of post-traumatic
stress disorder (PTSD). Despite considerable research devoted to the effect of cannabinoid …

Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we
identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging …

Background and Purpose Women are twice as likely as men to develop post‐traumatic
stress disorder (PTSD) making the search for biological mechanisms underlying these …

Abstract The endogenous cannabinoid, 2-arachidonoylglycerol (2-AG), plays a key role in
the regulation of anxiety-and stress-related behavioral phenotypes and may represent a …

Early and progressive cortico-striatal circuit alterations have been widely characterized in
Huntington's disease (HD) patients. Cortical premotor area, M2 cortex in rodents, is the most …

Although mice mostly communicate in the ultrasonic range, they also emit audible calls. We
demonstrate that mice selectively bred for high anxiety-related behavior (HAB) have a high …

Elucidating the underlying molecular mechanisms regulating fear and extinction learning
may offer insights that can lead to novel treatments for debilitating anxiety and trauma …

Innate defensive responses, though primarily instinctive, must also be highly adaptive to
changes in risk assessment. However, adaptive changes can become maladaptive …

Defensive behavioral responses are essential for survival in threating situations. The
superior colliculus (SC) has been implicated in the generation of defensive behaviors …