NGLY1/Ngly1 is a cytosolic peptide: N-glycanase, ie. de-N-glycosylating enzyme acting on
N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated …

Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and
mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired …

Abstract Peptide: N-glycanase (PNGase) is a de-N-glycosylating enzyme that cleaves intact
N-glycans from glycoproteins/glycopeptides. The activity of the cytoplasmic PNGase in …

Purpose: The endoplasmic reticulum–associated degradation pathway is responsible for the
translocation of misfolded proteins across the endoplasmic reticulum membrane into the …

The linear ubiquitin (Ub) chain assembly complex (LUBAC) generates Met1-linked" linear"
Ub chains that regulate the activation of the nuclear factor κB (NFκB) transcription factor and …

Abstract The AAA+ ATPase p97/VCP together with different sets of substrate-delivery
adapters and accessory cofactor proteins unfolds ubiquitinated substrates to facilitate …

NGLY1‐related disorder is a newly described autosomal recessive condition characterized
by neurological, hepatic, ophthalmological findings and associated with dysmorphic …

Targeting nuclear factor-kappa B (NF-κB) represents a highly viable strategy against
chemoresistance in cancers as well as cell death. Ubiquitination, including linear …

A moonlighting protein is one, which carries out multiple, often wholly unrelated, functions.
The RAD23 protein is a fascinating example of this, where the same polypeptide and the …

To understand a biological system, it is important to observe structures of biomolecules in
the solution where the system is functionalized. S mall-A ngle X-ray S cattering coupled with …