Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …

The post-translational modification of proteins regulates many biological processes. Their
dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications …

Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to
regulate such cellular processes as nuclear transport, transcription, chromosome …

The modification of proteins with ubiquitin chains can change their localization, activity
and/or stability. Although ubiquitylation requires the concerted action of ubiquitin-activating …

The regulation of protein fate by modification with the small ubiquitin-related modifier
(SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly …

Eukaryotic cells are equipped to degrade proteins via the ubiquitin–proteasome system
(UPS). Proteins become degraded upon their conjugation to chains of ubiquitin where they …

Attachment of ubiquitin or ubiquitin-like proteins (known as UBLs) to their targets through
multienzyme cascades is a central mechanism to modulate protein functions. This process is …

The NEDD8-activating enzyme (NAE) initiates a protein homeostatic pathway essential for
cancer cell growth and survival. MLN4924 is a selective inhibitor of NAE currently in clinical …

The family of ubiquitin‐conjugating (E2) enzymes is characterized by the presence of a
highly conserved ubiquitin‐conjugating (UBC) domain. These domains accommodate the …