In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Mood disorders such as major depressive disorder and bipolar disorder are chronic and
recurrent illnesses that cause significant disability and affect approximately 350 million …

The influence of the gut microbiota on brain chemistry has been convincingly demonstrated
in rodents. In the absence of gut bacteria, the central expression of brain derived neurotropic …

In acute ischaemic brain injury and chronic neurodegeneration, the primary step leading to
excitotoxicity and cell death is the excessive and/or prolonged activation of glutamate (Glu) …

Spinal cord injury (SCI) is a debilitating condition in which inflammatory responses in the
secondary phase of injury leads to long lasting sensory-motor dysfunction. The medicinal …

In acute ischaemic brain injury and chronic neurodegeneration, the first step leading to
excitotoxicity and cell death is the excessive release of Glu and the prolonged activation of …

Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the
pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and …

It is known that some antidepressants and antipsychotics directly inhibit NMDA-type
ionotropic glutamate receptors. In this study we systematically studied action of seven drugs …

Objective Geriatric depression is difficult to treat and frequently accompanied by cognitive
complaints that increase risk for dementia. New treatment strategies targeting both …

Current perspectives on the molecular underpinnings of major depressive disorder (MDD)
posit a mechanistic role of epigenetic DNA modifications in mediating the interaction …