Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen
and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers …

Fluorinated amino acids play a crucial role as fundamental components in drug synthesis
owing to their favorable attributes that enhance the pharmacokinetic properties of drugs …

Abstract β-Branched aromatic α-amino acids are valuable building blocks in natural
products and pharmaceutically active compounds. However, their chemical or enzymatic …

In this study, rational design and saturation mutagenesis efforts for engineering
phenylalanine ammonia-lyase from Petroselinum crispum (Pc PAL) provided tailored PALs …

Phenylalanine ammonia lyase (PAL) enzymes have been extensively exploited to produce
differently substituted arylalanine analogues, but their use in the stereoselective synthesis of …

Abstract Characterization of the aromatic ammonia–lyase from Loktanella atrilutea (LaAAL)
revealed reduced activity towards canonical AAL substrates: l‐Phe, l‐Tyr, and l‐His …