The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …

The sodium channel Nav1. 6, encoded by the gene SCN8A, is one of the major voltage-
gated channels in human brain. The sequences of sodium channels have been highly …

We describe a protocol for the production of mice carrying N-ethyl-N-nitrosourea (ENU)
mutations and their screening for auditory and vestibular phenotypes. In comparison with the …

Voltage-gated sodium channels produce fast depolarization, which is responsible for the
rising phase of the action potential in neurons, muscles and heart. These channels are very …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death amongst
patients whose seizures are not adequately controlled by current therapies. Patients with …

Background The mammalian inner ear contains sensory organs, the organ of Corti in the
cochlea and cristae and maculae in the vestibule, with each comprised of patterned sensory …

The fruit fly Drosophila melanogaster has provided important insights into how sensory
information is transduced by transient receptor potential (TRP) channels in the peripheral …

Understanding the role of SCN8A in epilepsy and behavior is critical in light of recently
identified human SCN8A epilepsy mutations. We have previously demonstrated that Scn8a …

The voltage-gated sodium channel Na v 1.6, encoded by the SCN8A gene, is one of the
most abundant sodium channels in human brain. In the axon initial segment of neurons, Na …

Propofol is one of the main sedatives but its negative side effects limit its clinical application.
Chitosan oligosaccharide (COS), a kind of natural product with anti-pain and anti …