The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Background For patients receiving therapy with oral anticoagulants (OACs), the proportion of
time spent in the therapeutic range (ie, anticoagulation control) is strongly associated with …

Background—The comparative safety of dabigatran versus warfarin for treatment of
nonvalvular atrial fibrillation in general practice settings has not been established. Methods …

Background Effectiveness and safety of warfarin is associated with the time in therapeutic
range (TTR) with an international normalised ratio (INR) of 2· 0–3· 0. In the Randomised …

Aims We sought to evaluate the frequency of early hypo-attenuated leaflet thickening (HALT)
of the SAPIEN 3 transcatheter aortic valve (S3). Methods and results Of 249 patients who …

Background—Oral anticoagulation (OAC) therapy is effective in atrial fibrillation but requires
vigilance to maintain the international normalized ratio in the therapeutic range. This report …

Importance Dabigatran and rivaroxaban are non–vitamin K oral anticoagulants approved for
stroke prevention in patients with nonvalvular atrial fibrillation (AF). There are no …

Although there is no need for routine coagulation monitoring with rivaroxaban–an oral, direct
factor Xa inhibitor–a haemostasis assay might be valuable to measure its pharmacodynamic …

BACKGROUND: Atrial fibrillation (AF) affects a significant proportion of the American
population and increases ischemic stroke risk by 4-to 5-fold. Oral vitamin K antagonists …

Atrial fibrillation (AF) is of public health importance and profoundly increases morbidity,
mortality, and healthrelated expenditures. Morbidities include the increased risks of …