Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

Parkinson's disease (PD) is histologically characterized by the accumulation of α-synuclein
particles, known as Lewy bodies. The second most common neurodegenerative disorder …

Mutations in the parkin gene result in an autosomal recessive juvenile-onset form of
Parkinson's disease. As an E3 ubiquitin-ligase, parkin promotes the attachment of ubiquitin …

Purinergic signaling modulates dopaminergic neurotransmission in health and disease.
Classically adenosine A 1 and A 2A receptors have been considered key for the fine tune …

Epidemiological and experimental evidence indicates that nicotine is protective for
Parkinson disease vulnerable dopamine neurons, but the underlying mechanism of this …

Inflammation arises in the CNS from a number of neurodegenerative and oncogenic
disorders, as well as from ischemic and traumatic brain injuries. These pathologies give rise …

Parkin-related mitophagy is vital for endothelial cell viability and the development of
atherosclerosis, although the upstream regulatory factor underlying Parkin-mediated …

Background Dietary fat consumption, involved in the pathogenesis of insulin resistance and
impaired glucose metabolism, is linked with decline in cognitive functions, dementia, and …

Parkinson disease (PD) is a degenerative brain disorder characterized by motor symptoms
that are unequivocally associated with the loss of dopaminergic (DA) neurons in the …

The past decade in Parkinson's disease (PD) research has been punctuated by numerous
advances in understanding genetic factors that contribute to the disease. Common to most of …