Antiviral alkaloid principles of the plant family Amaryllidaceae

JJ Nair, J van Staden - Phytomedicine, 2023 - Elsevier
Background Viral-borne diseases are amongst the oldest diseases known to mankind. They
are responsible for some of the most ravaging effects wrought on human health and well …

Aid or antagonize: nuclear long noncoding RNAs regulate host responses and outcomes of viral infections

V Kulkarni, S Jayakumar, M Mohan, S Kulkarni - Cells, 2023 - mdpi.com
Long noncoding RNAs (lncRNAs) are transcripts measuring> 200 bp in length and devoid of
protein-coding potential. LncRNAs exceed the number of protein-coding mRNAs and …

The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter

TC Chao, Q Zhang, Z Li, SK Tiwari, Y Qin, E Yau… - MBio, 2019 - Am Soc Microbiol
ABSTRACT A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying
and eradicating persistent reservoirs of replication-competent provirus. Long noncoding …

Amaryllidaceae alkaloid cherylline inhibits the replication of dengue and Zika viruses

S Ka, N Merindol, AA Sow, A Singh… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Dengue fever, caused by dengue virus (DENV), is the most prevalent arthropod-borne viral
disease and is endemic in many tropical and subtropical parts of the world, with an …

[PDF][PDF] Interactomics: dozens of viruses, co-evolving with humans, including the influenza A virus, may actively distort human aging

J Teulière, C Bernard, H Bonnefous… - Molecular biology …, 2023 - academic.oup.com
Some viruses (eg, human immunodeficiency virus 1 and severe acute respiratory syndrome
coronavirus 2) have been experimentally proposed to accelerate features of human aging …

Tissue-specific transcriptome sequencing analysis expands the non-human primate reference transcriptome resource (NHPRTR)

X Peng, J Thierry-Mieg, D Thierry-Mieg… - Nucleic acids …, 2015 - academic.oup.com
The non-human primate reference transcriptome resource (NHPRTR, available online at
http://nhprtr. org/) aims to generate comprehensive RNA-seq data from a wide variety of non …

Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals

S Moron-Lopez, S Telwatte, I Sarabia, E Battivelli… - PLoS …, 2020 - journals.plos.org
It is unclear what mechanisms govern latent HIV infection in vivo or in primary cell models.
To investigate these questions, we compared the HIV and cellular transcription profile in …

A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2

KD Pedro, LM Agosto, JA Sewell… - Proceedings of the …, 2021 - National Acad Sciences
The molecular networks involved in the regulation of HIV replication, transcription, and
latency remain incompletely defined. To expand our understanding of these networks, we …

Biological Investigation of Amaryllidaceae Alkaloid Extracts from the Bulbs of Pancratium trianthum Collected in the Senegalese Flora

S Ka, N Mérindol, I Seck, S Ricard, A Diop, CSB Boye… - Molecules, 2021 - mdpi.com
Amaryllidaceae plants are rich in alkaloids with biological properties. Pancratium trianthum
is an Amaryllidaceae species widely used in African folk medicine to treat several diseases …

Long non-coding RNAs and latent HIV–A search for novel targets for latency reversal

W Trypsteen, CH White, A Mukim, CA Spina… - PLoS …, 2019 - journals.plos.org
The latent cellular reservoir of HIV is recognized as the major barrier to cure from HIV
infection. Long non-coding RNAs (lncRNAs) are more tissue and cell type-specific than …