Endogenous glucocorticoids are crucial to various physiological processes, including
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …

Glucocorticoids (GCs) are small lipid hormones produced by the adrenals that maintain
organismal homeostasis. Circadian and stress-induced changes in systemic GC levels …

Glucocorticoids regulate fundamental processes of the human body and control cellular
functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover …

Animals receive environmental stimuli from neural signals in order to produce hormones that
control immune responses. Glucocorticoids (GCs) are a group of steroid hormones …

Pulmonary immune homeostasis is maintained by a network of tissue-resident cells that
continually monitor the external environment, and in health, instruct tolerance to innocuous …

Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its
recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and …

Background Infection after surgery and trauma is a major cause of increased morbidity,
mortality, and cost. Alterations of the hosts immune system following these insults is believed …

Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of
numerous (autoimmune) inflammatory diseases. They exert their actions by binding to the …

BACKGROUND: Cross-sectional studies suggest that maternal exposure to farming
decreases the risk of allergic diseases in offspring. The potential underlying immunologic …

Glucocorticoids (GC) are the mainstay treatment option for inflammatory conditions. Despite
the broad usage of GC, the mechanisms by which GC exerts its effects remain elusive. Here …