An inflammation-centric view of neurological disease: beyond the neuron

SD Skaper, L Facci, M Zusso, P Giusti - Frontiers in cellular …, 2018 - frontiersin.org
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration

D Kempuraj, R Thangavel, GP Selvakumar… - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

Inflammation and neuro-immune dysregulations in autism spectrum disorders

D Siniscalco, S Schultz, AL Brigida, N Antonucci - Pharmaceuticals, 2018 - mdpi.com
Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social
communication and interaction and restricted-repetitive patterns of behavior, interests, or …

Blood-brain barrier regulation in psychiatric disorders

J Kealy, C Greene, M Campbell - Neuroscience letters, 2020 - Elsevier
The blood-brain barrier (BBB) is a dynamic interface between the peripheral blood supply
and the cerebral parenchyma, controlling the transport of material to and from the brain …

Analysis of gut microbiota profiles and microbe-disease associations in children with autism spectrum disorders in China

M Zhang, W Ma, J Zhang, Y He, J Wang - Scientific reports, 2018 - nature.com
Autism spectrum disorder (ASD) is a set of complex neurodevelopmental disorders. Recent
studies reported that children with ASD have altered gut microbiota profiles compared with …

Molecular mechanisms of neurogenic inflammation of the skin

L Marek-Jozefowicz, B Nedoszytko… - International Journal of …, 2023 - mdpi.com
The skin, including the hypodermis, is the largest body organ and is in constant contact with
the environment. Neurogenic inflammation is the result of the activity of nerve endings and …

Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders

TC Theoharides, I Tsilioni, AB Patel, R Doyle - Translational psychiatry, 2016 - nature.com
Autism spectrum disorders (ASDs) affect as many as 1 in 45 children and are characterized
by deficits in sociability and communication, as well as stereotypic movements. Many …

Mast cells in neuroinflammation and brain disorders

E Hendriksen, D van Bergeijk, RS Oosting… - Neuroscience & …, 2017 - Elsevier
It is well recognized that neuroinflammation is involved in the pathogenesis of various
neurodegenerative diseases. Microglia and astrocytes are major pathogenic components …

Key role of DAMP in inflammation, cancer, and tissue repair

F Pandolfi, S Altamura, S Frosali, P Conti - Clinical therapeutics, 2016 - Elsevier
Purpose This review aimed to take stock of the current status of research on damage-
associated molecular pattern (DAMP) protein. We discuss the Janus-faced role of DAMP …

Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

TC Theoharides, JM Stewart, E Hatziagelaki… - Frontiers in …, 2015 - frontiersin.org
Brain “fog” is a constellation of symptoms that include reduced cognition, inability to
concentrate and multitask, as well as loss of short and long term memory. Brain “fog” …