The SLC4 family of bicarbonate (HCO3-) transporters
The SLC4 family consists of 10 genes (SLC4A1–5; SLC4A7–11). All encode integral
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential
P Wangemann - The Journal of physiology, 2006 - Wiley Online Library
The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into
nerve impulses, depends on the endocochlear potential and requires a highly specialized …
nerve impulses, depends on the endocochlear potential and requires a highly specialized …
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters
MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
Recent advances in the transmembrane transport of anions
Anions cannot diffuse passively through biological membranes and membrane-bound
proteins mainly govern the transmembrane movement of these charged species. The use of …
proteins mainly govern the transmembrane movement of these charged species. The use of …
Structure–activity relationships in tripodal transmembrane anion transporters: the effect of fluorination
A series of easy-to-make fluorinated tripodal anion transporters containing urea and
thiourea groups have been prepared and their anion transport properties studied. Vesicle …
thiourea groups have been prepared and their anion transport properties studied. Vesicle …
The SLC4 family of HCO3 − transporters
MF Romero, CM Fulton, WF Boron - Pflügers Archiv, 2004 - Springer
The SLC4 family consists of ten genes. All appear to encode integral membrane proteins
with very similar hydropathy plots—consistent with the presence of 10–14 transmembrane …
with very similar hydropathy plots—consistent with the presence of 10–14 transmembrane …
Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II
MD Weston, MWJ Luijendijk, KD Humphrey… - The American Journal of …, 2004 - cell.com
Usher syndrome type II (USH2) is a genetically heterogeneous autosomal recessive
disorder with at least three genetic subtypes (USH2A, USH2B, and USH2C) and is classified …
disorder with at least three genetic subtypes (USH2A, USH2B, and USH2C) and is classified …
Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease
J Reiners, K Nagel-Wolfrum, K Jürgens, T Märker… - Experimental eye …, 2006 - Elsevier
Usher syndrome (USH) is the most frequent cause of combined deaf-blindness in man. It is
clinically and genetically heterogeneous and at least 12 chromosomal loci are assigned to …
clinically and genetically heterogeneous and at least 12 chromosomal loci are assigned to …
[HTML][HTML] Minireview: pH and synaptic transmission
As a general rule a rise in pH increases neuronal activity, whereas it is dampened by a fall of
pH. Neuronal activity per se also challenges pH homeostasis by the increase of metabolic …
pH. Neuronal activity per se also challenges pH homeostasis by the increase of metabolic …
Loss of cochlear HCO3− secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model
P Wangemann, K Nakaya, T Wu… - American Journal …, 2007 - journals.physiology.org
Pendred syndrome, characterized by childhood deafness and postpuberty goiter, is caused
by mutations of SLC26A4, which codes for the anion exchanger pendrin. The goal of the …
by mutations of SLC26A4, which codes for the anion exchanger pendrin. The goal of the …