Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Ageing is a complex and multifactorial process. For two decades, the Human Ageing
Genomic Resources (HAGR) have aided researchers in the study of various aspects of …

Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …

We propose a two-mode (pursuit/maintenance) model of metabolism defined by usable
resource availability. Pursuit, consisting of anabolism and catabolism, dominates when …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Naked mole rats (NMRs) are the longest‐lived rodents yet their stem cell characteristics
remain enigmatic. Here, we comprehensively mapped the NMR hematopoietic landscape …

Abstract Changes in DNA methylation (DNAm) are linked to aging. Here, we profile highly
conserved CpGs in 339 predominantly female mice belonging to the BXD family for which …

Ageing is a biological process that is linked to a functional decline, ultimately resulting in
death. Large interindividual differences exist in terms of life‐and healthspan, representing …