Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

R Ruze, J Song, X Yin, Y Chen, R Xu… - Signal transduction and …, 2023 - nature.com
Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment

H Yao, S He - Molecular Medicine Reports, 2021 - spandidos-publications.com
Adipocytes are a type of stromal cell found in numerous different tissues that serve an active
role in the tumor microenvironment. Cancer‑associated adipocytes (CAAs) display a …

Obesity and main urologic cancers: Current systematic evidence, novel biological mechanisms, perspectives and challenges

G Papavasileiou, D Tsilingiris, N Spyrou… - Seminars in Cancer …, 2023 - Elsevier
Urologic cancers (UC) account for 13.1% of all new cancer cases and 7.9% of all cancer-
related deaths. A growing body of evidence has indicated a potential causal link between …

Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

E Hazelwood, E Sanderson, VY Tan, KS Ruth… - BMC medicine, 2022 - Springer
Background Endometrial cancer is the most common gynaecological cancer in high-income
countries. Elevated body mass index (BMI) is an established modifiable risk factor for this …

Obesity and pancreatic cancer: insight into mechanisms

G Eibl, E Rozengurt - Cancers, 2021 - mdpi.com
Simple Summary Obesity is recognized as a chronic progressive disease and risk factor for
many human diseases. The high and increasing number of obese people may underlie the …

Associations between potential causal factors and colorectal cancer risk: A systematic review and meta‐analysis of Mendelian randomization studies

Y Deng, L Wang, J Huang, H Ding… - Journal of digestive …, 2022 - Wiley Online Library
Objective To summarize the associations between potential causal factors and colorectal
cancer (CRC) risk based on existing Mendelian randomization studies. Methods This …

The impact of obesity and adipokines on breast and gynecologic malignancies

S Tewari, R Vargas, O Reizes - … of the New York Academy of …, 2022 - Wiley Online Library
The link between obesity and multiple disease comorbidities is well established. In 2003,
Calle and colleagues presented the relationship between obesity and several cancer types …

Obesity associated pancreatic ductal adenocarcinoma: Therapeutic challenges

M Srilatha, R Malla, MP Adem, JB Foote… - Seminars in Cancer …, 2023 - Elsevier
Obesity is a prominent health issue worldwide and directly impacts pancreatic health, with
obese individuals exhibiting a significant risk for increasing pancreatic ductal …

10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation

X Wang, DM Glubb, TA O'Mara - EBioMedicine, 2022 - thelancet.com
Endometrial cancer is a common gynaecological cancer with increasing incidence and
mortality. In the last decade, endometrial cancer genome-wide association studies (GWAS) …

Review of mendelian randomization studies on endometrial cancer

JZ Guo, QJ Wu, FH Liu, C Gao, TT Gong… - Frontiers in …, 2022 - frontiersin.org
Endometrial cancer (EC) is a common gynecological cancer. In some parts of the world, the
incidence and mortality of EC are on the rise. Understanding the risk factors of EC is …