Tendon injuries are a common cause of physical disability. They present a clinical challenge
to orthopedic surgeons because injured tendons respond poorly to current treatments …

Human pluripotent embryonic stem cells have two special features: self-renewal and
pluripotency. It is important to understand the properties of pluripotent stem cells and …

Tendon injury is a common disorder of the musculoskeletal system caused by overuse or
trauma. With increasing incidence of tendon injuries, it is necessary to find an effective …

Iatrogenic tumorigenesis is a major limitation for the use of human induced pluripotent stem
cells (hiPSCs) in hematology. The teratoma risk comes from the persistence of hiPSCs in …

Stem cell therapy is a promising approach to the treatment of ischemic heart disease via
replenishing cell loss after myocardial infarction. Both preclinical studies and clinical trials …

Induced pluripotent stem cells (iPSC) have a great potential, but their clinical application
depends on finding strategies to abolish their tumorigenic potential. The use of Oct4, Sox2 …

Human induced pluripotent stem cells (iPSCs) and derived progeny provide invaluable
regenerative platforms, yet their clinical translation has been compromised by their biosafety …

Spinal cord injury (SCI) causes loss of neural functions below the level of the lesion due to
interruption of spinal pathways and secondary neurodegenerative processes. The transplant …

Ligament, cartilage, and meniscus injuries often have poor healing due to low vascularity
and low proliferative abilities of the resident cells. Drawbacks with conventional treatment …

Stem cells harbor significant potential for regenerative medicine as well as basic and clinical
translational research. Prior to harnessing their reparative nature for degenerative diseases …