Abstract BCR:: ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases
originating from a single hematopoietic stem cell that cause excessive production of mature …

Philadelphia-negative classical myeloproliferative neoplasms (MPNs) include polycythemia
vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The 2016 …

Background The myelodysplastic syndromes and myeloproliferative disorders are
associated with deregulated production of myeloid cells. The mechanisms underlying these …

The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non‐
receptor protein tyrosine kinases. They are involved in cell growth, survival, development …

Recently, a gain-of-function MPL mutation, MPL W515L, was described in patients with
JAK2 V617F-negative myelofibrosis with myeloid metaplasia (MMM). To gain more …

The discovery of an identical mutation (V617F) of the JAK2 gene in patients with
polycythemia vera, essential thrombocythemia, and myelofibrosis—the principal …

Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by excessive
production of mature blood cells. In the majority of classic MPN—polycythemia vera …

The myeloproliferative disorders polycythaemia vera (PV), essential thombocythaemia (ET),
and primary myelofibrosis (PMF) are clonal disorders of multipotent haematopoietic …

Abstract JAK2 617V> F mutation occurs in a homozygous state in 25% to 30% of patients
with polycythemia vera (PV) and 2% to 4% with essential thrombocythemia (ET). Whether …

Our understanding of the genetic basis of myeloproliferative neoplasms began in 2005,
when the JAK2 (V617F) mutation was identified in polycythemia vera, essential …