The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an
electrophysiologic curiosity to a centerpiece in drug regulation and development. This …

Marked QT prolongation and torsades de pointes can occur not only in the congenital long
QT syndromes (LQTSs) but also as a consequence of environmental stimuli, notably …

Background—The Brugada syndrome is characterized by marked ST-segment elevation in
the right precordial ECG leads and is associated with a high incidence of sudden and …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

Background Recordings of outward currents in human ventricular myocytes revealed the
presence of a large calcium-insensitive transient outward current. This current has been …

Background Torsade de pointes often occurs with underlying hypokalemia and bradycardia.
A common effect of many drugs producing torsade de pointes is block of the rapidly …

Limited information is available about transmural heterogeneity in cardiac electrophysiology
in man. The present study was designed to evaluate heterogeneity of cardiac action …

Aseries of 1-alkylaminomethylnaphthols have been prepared. These compounds were
readily prepared in good yields by addition of 2-naphthol to formalin and alkylamines. The …

1. In rabbit and human hearts there are significant differences in the action potential
configuration in atrium and ventricle, and the action potential waveform exhibits marked …

J Wave Associated Ventricular Fibrillation. Recurrent ventricular fibrillation was observed in
a 29‐year‐old Vietnamese man who did not exhibit structural heart disease. The patient's …