ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …

As a consequence of an increasingly aging population, the number of people affected by
neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and …

Wnt5a is a representative ligand that activates the β‐catenin‐independent pathways.
Because the β‐catenin‐independent pathway includes multiple signalling cascades in …

In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained
prominence in several diseases of the central nervous system, especially in glioblastoma …

The Wnt/β-catenin signaling pathway is crucial to regulate cell proliferation and polarity, cell
determination, and tissue homeostasis. The activation of Wnt/β-catenin signaling is based …

Astrocytes are involved in non‐cell‐autonomous pathogenic cascades in amyotrophic
lateral sclerosis (ALS); however, their role is still debated. We show that astrocytic NF‐κB …

Background Alzheimer's disease (AD) brain shows an ongoing inflammatory condition and
non-steroidal anti-inflammatories diminish the risk of suffering the neurologic disease …

Microglia, the resident immune cells of the brain, can take on a range of pro-or anti-
inflammatory phenotypes to maintain homeostasis. However, the sustained activation of pro …

The wingless/int1 (WNT)/F rizzled (FZD) signalling pathway controls numerous cellular
processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a …