Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Dietary salt intake increases blood pressure (BP) but the salt sensitivity of BP differs
between individuals. The interplay of ageing, genetics and environmental factors, including …

Background: Intraoperative hypotension (IOH) may be associated with postoperative acute
kidney injury (AKI), but the duration of hypotension for triggering harm is unclear. The …

Aging is associated with a high prevalence of hypertension due to elevated susceptibility of
BP to dietary salt, but its mechanism is unknown. Serum levels of Klotho, an anti-aging …

Arterial hypertension is a risk factor for several pathologies, mainly including cardio-
cerebrovascular diseases, which rank as leading causes of morbidity and mortality …

Background and Purpose Generation of cGMP via NO‐sensitive soluble guanylyl cyclase
(sGC) has been implicated in the regulation of renal functions. Chronic kidney disease …

Background Abnormal renal hemodynamic responses to salt‐loading are thought to
contribute to salt‐sensitive (SS) hypertension. However, this is based largely on studies in …

A high amount of salt in the diet increases blood pressure (BP) and leads to salt-sensitive
hypertension in individuals with impaired renal sodium excretion. Small guanosine …

Key points Our understanding of the mechanisms underlying the role of hypoxia in the
initiation and progression of renal disease remains rudimentary. We have developed a …

The relative contribution of self-perpetuating versus hemodynamic-induced fibrosis to the
progression of chronic kidney disease (CKD) after acute kidney injury (AKI) is unclear. In the …