Classification of intrinsically disordered regions and proteins
Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …
Effect of trehalose on protein structure
Trehalose is a ubiquitous molecule that occurs in lower and higher life forms but not in
mammals. Till about 40 years ago, trehalose was visualized as a storage molecule, aiding …
mammals. Till about 40 years ago, trehalose was visualized as a storage molecule, aiding …
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
Various physics-and data-driven sequence-dependent protein coarse-grained models have
been developed to study biomolecular phase separation and elucidate the dominant …
been developed to study biomolecular phase separation and elucidate the dominant …
Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics
INTRODUCTION Enzymes possess extraordinary catalytic proficiency and specificity. These
properties ultimately derive from interactions not just between the active-site residues and …
properties ultimately derive from interactions not just between the active-site residues and …
Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs
Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many
biomolecular condensates, eukaryotic cell structures that concentrate diverse …
biomolecular condensates, eukaryotic cell structures that concentrate diverse …
Advances in understanding stimulus-responsive phase behavior of intrinsically disordered protein polymers
Proteins and synthetic polymers can undergo phase transitions in response to changes to
intensive solution parameters such as temperature, proton chemical potentials (pH), and …
intensive solution parameters such as temperature, proton chemical potentials (pH), and …
Interactions of formulation excipients with proteins in solution and in the dried state
S Ohtake, Y Kita, T Arakawa - Advanced drug delivery reviews, 2011 - Elsevier
A variety of excipients are used to stabilize proteins, suppress protein aggregation, reduce
surface adsorption, or to simply provide physiological osmolality. The stabilizers encompass …
surface adsorption, or to simply provide physiological osmolality. The stabilizers encompass …
Chemistry of Hofmeister anions and osmolytes
The study of the interactions of salts and osmolytes with macromolecules in aqueous
solution originated with experiments concerning protein precipitation more than 100 years …
solution originated with experiments concerning protein precipitation more than 100 years …
Osmolyte effects on protein stability and solubility: A balancing act between backbone and side-chains
In adaptation biology the discovery of intracellular osmolyte molecules that in some cases
reach molar levels, raises questions of how they influence protein thermodynamics. We've …
reach molar levels, raises questions of how they influence protein thermodynamics. We've …
Industrial production of the cell protectant ectoine: protection mechanisms, processes, and products
Bacteria, Archaea and Eukarya can adapt to Saline environments by accumulating
compatible solutes in order to maintain an osmotic equilibrium. Compatible solutes are of …
compatible solutes in order to maintain an osmotic equilibrium. Compatible solutes are of …