Molecular mechanisms of early and late LTP
LTP is the most intensively studied cellular model of the memory and generally divided at
least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates …
least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates …
What does LTP tell us about the roles of CaMKII and PKMζ in memory?
TC Sacktor, AA Fenton - Molecular brain, 2018 - Springer
In “Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ),” Lisman
proposes that elucidating the mechanism of LTP maintenance is key to understanding …
proposes that elucidating the mechanism of LTP maintenance is key to understanding …
The role of PKMζ in the maintenance of long-term memory: a review
H Patel, R Zamani - Reviews in the Neurosciences, 2021 - degruyter.com
Long-term memories are thought to be stored in neurones and synapses that undergo
physical changes, such as long-term potentiation (LTP), and these changes can be …
physical changes, such as long-term potentiation (LTP), and these changes can be …
Neuropeptide S promotes maintenance of newly formed dendritic spines and performance improvement after motor learning in mice
C Li, XJ Wu, W Li - Peptides, 2022 - Elsevier
Neuropeptide S (NPS), an endogenous neuropeptide consisting of 20 amino acids,
selectively binds and activates G protein-coupled receptor named neuropeptide S receptor …
selectively binds and activates G protein-coupled receptor named neuropeptide S receptor …
Synaptic plasticity/dysplasticity, process memory and item memory in rodent models of mental dysfunction
Activity-dependent changes in the effective connection strength of synapses are a
fundamental feature of a nervous system. This so-called synaptic plasticity is thought to …
fundamental feature of a nervous system. This so-called synaptic plasticity is thought to …
Superresolution fluorescence microscopy for 3D reconstruction of thick samples
Abstract Three-dimensional (3D) reconstruction of thick samples using superresolution
fluorescence microscopy remains challenging due to high level of background noise and …
fluorescence microscopy remains challenging due to high level of background noise and …
PKMζ maintains remote contextual fear memory by inhibiting GluA2-dependent AMPA receptor endocytosis in the prelimbic cortex
LA Marcondes, JC Myskiw, EG Nachtigall, RF Narvaes… - Neuroscience, 2022 - Elsevier
Fear memories allow animals to recognize and adequately respond to dangerous situations.
The prelimbic cortex (PrL) is a crucial node in the circuitry that encodes contextual fear …
The prelimbic cortex (PrL) is a crucial node in the circuitry that encodes contextual fear …
Memory destabilization and reconsolidation dynamically regulate the PKMζ maintenance mechanism
M Bernabo, J Haubrich, K Gamache… - Journal of …, 2021 - Soc Neuroscience
Useful memory must balance between stability and malleability. This puts effective memory
storage at odds with plasticity processes, such as reconsolidation. What becomes of memory …
storage at odds with plasticity processes, such as reconsolidation. What becomes of memory …
Transcription-independent expression of PKM ζ in the anterior cingulate cortex contributes to chronically maintained neuropathic pain
Protein kinase M ζ is well known for its role in maintaining memory and pain. Previously, we
revealed that the activation of protein kinase M ζ in the anterior cingulate cortex plays a role …
revealed that the activation of protein kinase M ζ in the anterior cingulate cortex plays a role …
PKMζ in the nucleus accumbens acts to dampen cocaine seeking
The constitutively active, atypical protein kinase C, protein kinase M-ζ (PKMζ), is exclusively
expressed in the brain and its expression increases following exposure to drugs of abuse …
expressed in the brain and its expression increases following exposure to drugs of abuse …