Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in
combination with other drugs, restores the ovarian function in women with polycystic ovary …

Initially produced in Europe in 1958, metformin is still one of the most widely prescribed
drugs to treat type II diabetes and other comorbidities associated with insulin resistance …

Background Metformin has long been used for glycemic control in diabetic state. Recently,
other benefits of metformin beyond blood glucose regulation have emerged. Objectives To …

Purpose The study aims to elucidate the changes in testicular spermatogenic function in
high-fat diet (HFD)-induced obese rats and to evaluate the protective effects of metformin …

Diabetes mellitus (DM) is a major health problem that affects patients' quality of life quality
throughout the world due to its many complications. Reproductive dysfunction is one of the …

Context: Metformin's effect on glycaemic control is well documented, but its effect on
diabetes-induced testicular impairment has been scarcely reported. Objective: To …

Background: Uncontrolled or long-term diabetes mellitus is conducive to vascular and
oxidative stress disturbances that impede several physiological systems, which may in turn …

Ethnopharmacological relevance Cornus officinalis (CO) has been widely used as a
traditional Chinese medicine for treating diabetes mellitus (DM) and its complications. Iridoid …

Testicular damage and testosterone secretion disorder are associated with diabetes
mellitus. Quercetin, a common flavonoid, has antioxidant, anti-cancer, and blood sugar …

Diabetes mellitus is a metabolic disease that can cause systemic problems, including
testicular dysfunction. Several diabetes medications have demonstrated potential adverse …