Sleep disturbances are commonly observed in schizophrenia, including in chronic, early-
course, and first-episode patients. This has generated considerable interest, both in clinical …

Psychiatry has a well-established tradition of comparing drug-induced experiences to
psychotic symptoms, based on shared phenomena such as altered perceptions. The present …

Thalamic dysfunction has been implicated in multiple psychiatric disorders. We sought to
study the mechanisms by which abnormalities emerge in the context of the 22q11. 2 …

Abnormalities in thalamocortical crosstalk can lead to neuropsychiatric disorders. Variants in
CACNA1G, which encodes the α1G subunit of the thalamus-enriched T-type calcium …

Sleep spindles, defining oscillations of stage 2 non-rapid eye movement sleep (N2), mediate
memory consolidation. Schizophrenia is characterized by reduced spindle activity that …

Neurexins are presynaptic transmembrane proteins crucial for synapse development and
organization. Deletion and missense mutations in all three Neurexin genes have been …

Schizophrenia is associated with alterations of sensory integration, cognitive processing and
both sleep architecture and sleep oscillations in mouse models and human subjects …

Psychosis spectrum disorder (PSD) affects 1% of the world population and results in a
lifetime of chronic disability, causing devastating personal and economic consequences …

There is converging evidence that abnormal thalamocortical interactions contribute to
attention deficits and sensory sensitivities in autism spectrum disorder (ASD). However …

Objective: Thalamus models of psychosis implicate association nuclei in the pathogenesis of
psychosis and mechanisms of cognitive impairment. Studies to date have provided …