CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte
populations show an increase in number and function after antigen encounter and more …

The skin is a site of constant dialog between the immune system and commensal bacteria.
However, the molecular mechanisms that allow us to tolerate the presence of skin …

Tissue-resident memory T cells (TRM) persist locally in nonlymphoid tissues where they
provide frontline defense against recurring insults. TRM at barrier surfaces express the …

Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling
is essential for establishing diverse cellular identities, but how the epigenetic program in …

Regulatory T cells (Tregs) offer new immunotherapeutic options to control undesired
immune reactions, such as those in transplant rejection and autoimmunity. In addition, tissue …

Restoration of barrier-tissue integrity after injury is dependent on the function of immune
cells and stem cells (SCs) residing in the tissue. In response to skin injury, hair-follicle stem …

At the center of fibrosing diseases is the aberrant activation of tissue fibroblasts. The cellular
and molecular mechanisms of how the immune system augments fibroblast activation have …

CD4+ T cells are critical components of the adaptive immune system. The T cell receptor
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …

Tumor microenvironment represents the site where the tumor tries to survive and escape
from immune system-mediated recognition. Indeed, to proliferate tumor cells can divert the …