The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …

The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

CD4+ follicular helper T (Tfh) cells play a vital role in providing help for B cells undergoing
selection and differentiation into activated antibody-secreting cells in mammalian germinal …

Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are
essential for germinal center formation, affinity maturation, and the development of most high …

Therapeutic targeting of immune checkpoints has garnered significant attention in the area
of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T …

The interactions of CD4+ T cells and B cells are fundamental for the generation of protective
antibody responses, as well as for the development of harmful autoimmune diseases …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic
T cell–B cell interactions and autoantibody production. Defining the T cell populations that …

The vast majority of currently licensed human vaccines work on the basis of long-term
protective antibody responses. It is now conceivable that an antibody-dependent HIV …

The role of immune system in various bone pathologies, such as osteoporosis, osteoarthritis,
and rheumatoid arthritis is now well established. This had led to the emergence of a modern …