In eukaryotes, the translation initiation codon is generally identified by the scanning
mechanism, wherein every triplet in the messenger RNA leader is inspected for …

Translation initiation in eukaryotes is a highly regulated and complex stage of gene
expression. It requires the action of at least 12 initiation factors, many of which are known to …

Ribosome-footprint profiling provides genome-wide snapshots of translation, but technical
challenges can confound its analysis. Here, we use improved methods to obtain ribosome …

Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …

This work summarizes our current understanding of the elongation and termination/recycling
phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In …

Translation initiation in eukaryotes is a complex and highly regulated process requiring the
action of at least 12 protein factors. The pathway is distinguished by the formation of a pre …

The correct translation of mRNA depends critically on the ability to initiate at the right AUG
codon. For most mRNAs in eukaryotic cells, this is accomplished by the scanning …

The transcriptome and proteome change dynamically as cells respond to environmental
stress; however, prior proteomic studies reported poor correlation between mRNA and …

As cells encounter adverse environmental conditions, such as hypoxia, oxidative stress or
nutrient deprivation, they trigger stress response pathways to protect themselves until …

Translation is a core cellular process carried out by a highly conserved macromolecular
machine, the ribosome. There has been remarkable evolutionary adaptation of this machine …