This review outlined evidence that purinergic signaling is involved in the modulation of
blood-brain barrier (BBB) permeability. The functional and structural integrity of the BBB is …

The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial
cells, separates the brain from the peripheral circulation. Together with other central nervous …

Numerous studies have shown that arsenic (As) is an important hazardous metalloid that is
commonly considered to have systemic toxicity. The main pathway of arsenic exposure is …

Multidrug-resistant (MDR) superbugs can breach the blood–brain barrier (BBB), leading to a
continuous barrage of pro-inflammatory modulators and induction of severe infection-related …

The incidence of infectious diseases affecting the central nervous system (CNS) has been
increasing over the last several years. Among the reasons for the expansion of these …

The difficulty to treat resistant strains-related hospital-acquired infections (HAIs) promoted
the study of phytoextracts, known sources of bioactive molecules. Accordingly, in the present …

Increased vascular permeability is a hallmark of several cardiovascular anomalies, including
ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and …

Escherichia coli continues to be the predominant Gram-negative pathogen causing neonatal
meningitis worldwide. Inflammatory mediators have been implicated in the pathogenesis of …

Background Brain pericytes participate in the regulation of cerebral blood flow and the
maintenance of blood–brain barrier integrity. Because of their perivascular localization, their …

Treponema pallidum subspecies pallidum, the causative agent of syphilis, traverses the
vascular endothelium to gain access to underlying tissue sites. Herein, we investigate the …