Ligand-targeted theranostic nanomedicines against cancer

VJ Yao, S D'Angelo, KS Butler, C Theron… - Journal of Controlled …, 2016 - Elsevier
Nanomedicines have significant potential for cancer treatment. Although the majority of
nanomedicines currently tested in clinical trials utilize simple, biocompatible liposome …

Tumor-targeting peptides from combinatorial libraries

R Liu, X Li, W Xiao, KS Lam - Advanced drug delivery reviews, 2017 - Elsevier
Cancer is one of the major and leading causes of death worldwide. Two of the greatest
challenges in fighting cancer are early detection and effective treatments with no or …

Combinatorial peptide libraries: mining for cell-binding peptides

BP Gray, KC Brown - Chemical reviews, 2014 - ACS Publications
The surface of a cell represents a collection of macromolecules, which provides the cell with
a unique cellular landscape specific to the type and state of the cell. Ligands that …

Targeted gene silencing using RGD-labeled chitosan nanoparticles

HD Han, LS Mangala, JW Lee, MMK Shahzad… - Clinical Cancer …, 2010 - AACR
Purpose: This study aimed to develop an Arg-Gly-Asp (RGD) peptide-labeled chitosan
nanoparticle (RGD-CH-NP) as a novel tumor targeted delivery system for short interfering …

Phage display in molecular imaging and diagnosis of cancer

SL Deutscher - Chemical reviews, 2010 - ACS Publications
New peptide-based probes to facilitate the molecular imaging of disease are rapidly
evolving due to implementation of combinatorial chemistry and bacteriophage (phage) …

Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes

AM Zama, M Uzumcu - Endocrinology, 2009 - academic.oup.com
Exposure to endocrine-disrupting chemicals during development could alter the epigenetic
programming of the genome and result in adult-onset disease. Methoxychlor (MXC) and its …

Knights in action: lectin receptor-like kinases in plant development and stress responses

N Vaid, A Macovei, N Tuteja - Molecular plant, 2013 - cell.com
The Receptor-Like Kinase (RLK) is a vast protein family with over 600 genes in Arabidopsis
and 1100 in rice. The Lectin RLK (LecRLK) family is believed to play crucial roles in …

[HTML][HTML] Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

JC Polf, LF Bronk, WHP Driessen, W Arap… - Applied physics …, 2011 - pubs.aip.org
The development and use of sensitizing agents to improve the effectiveness of radiotherapy
have long been sought to improve our ability to treat cancer. In this letter, we have studied …

Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis

E Dias-Neto, DN Nunes, RJ Giordano, J Sun, GH Botz… - PloS one, 2009 - journals.plos.org
Background Combinatorial phage display has been used in the last 20 years in the
identification of protein-ligands and protein-protein interactions, uncovering relevant …

A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys

KF Barnhart, DR Christianson, PW Hanley… - Science translational …, 2011 - science.org
Obesity, defined as body mass index greater than 30, is a leading cause of morbidity and
mortality and a financial burden worldwide. Despite significant efforts in the past decade …