The base excision repair (BER) pathway is essential for maintaining the stability of DNA in
all organisms and defects in this process are associated with life-threatening diseases. It is …

The activity of DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1), which excises
oxidized base 8-oxoguanine (8-OG) from DNA, is closely linked to mutagenesis …

In all organisms, DNA glycosylases initiate base excision repair pathways resulting in
removal of aberrant bases from DNA. Human SMUG1 belongs to the superfamily of uracil …

Enzymes in uracil-DNA glycosylase (UDG) superfamily are involved in removal of
deaminated nucleobases such as uracil, methylcytosine derivatives such as formylcytosine …

Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the removal of
uracil. Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded …

The human N-glycosylases SMUG1 and MBD4 catalyze the removal of uracil residues from
DNA resulting from cytosine deamination or replication errors. For polymorphic variants of …

Methylcytosine (mC) is an epigenetic mark that impacts transcription, development, diseases
including cancer and aging. The demethylation process involves Tet-mediated stepwise …

A recent phylogenetic study on UDG superfamily estimated a new clade of family 3 enzymes
(SMUG1-like), which shares a lower homology with canonic SMUG1 enzymes. The …

Base deamination is a common type of DNA damage that occurs in all organisms. DNA
repair mechanisms are essential to maintain genome integrity, in which the base excision …

Human SMUG1 (hSMUG1) hydrolyzes the N-glycosidic bond of uracil and some uracil
lesions formed in the course of epigenetic regulation. Despite the functional importance of …