New challenges in the management of cholangiocarcinoma: the role of liver transplantation, locoregional therapies, and systemic therapy

E Mauro, J Ferrer-Fàbrega, T Sauri, A Soler, A Cobo… - Cancers, 2023 - mdpi.com
Simple Summary Cholangiocarcinoma (CCA) is a highly lethal neoplasia, which incidence
has steadily increased in the last years. Although surgical resection remains the cornerstone …

[HTML][HTML] Molecular profiling in cholangiocarcinoma: a practical guide to next-generation sequencing

A Stenzinger, A Vogel, U Lehmann, A Lamarca… - Cancer Treatment …, 2024 - Elsevier
Cholangiocarcinomas (CCA) are a heterogeneous group of tumors that are classified as
intrahepatic, perihilar, or distal according to the anatomic location within the biliary tract …

EASL-ILCA Clinical Practice Guidelines on the management of intrahepatic cholangiocarcinoma

D Alvaro, GJ Gores, J Walicki, C Hassan… - Journal of …, 2023 - Elsevier
Intrahepatic cholangiocarcinoma (iCCA) develops inside the liver, between bile ductules
and the second-order bile ducts. It is the second most frequent primary liver cancer after …

Peptides targeting HER2-positive breast cancer cells and applications in tumor imaging and delivery of chemotherapeutics

PA Cavallaro, M De Santo, EL Belsito, C Longobucco… - Nanomaterials, 2023 - mdpi.com
Breast cancer represents the most common cancer type and one of the major leading
causes of death in the female worldwide population. Overexpression of HER2, a …

Intrahepatic cholangiocarcinoma: Evolving strategies in management and treatment

MC Bragazzi, R Venere, E Ribichini, F Covotta… - Digestive and Liver …, 2024 - Elsevier
Intrahepatic cholangiocarcinoma is the second most frequent primary liver cancer after
hepatocellular carcinoma. According to International Classification of Diseases-11 (ICD-11) …

[HTML][HTML] Precision medicine in the era of multi-omics: can the data tsunami guide rational treatment decision?

M Aldea, L Friboulet, S Apcher, F Jaulin, F Mosele… - ESMO open, 2023 - Elsevier
Highlights•Actionable alterations should be prioritized by using validated rankings for
treatment tailoring.•High-throughput genomics could refine drivers and find new targets, mini …

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving …

L Colyn, G Alvarez-Sola, MU Latasa, I Uriarte… - Journal of Experimental …, 2022 - Springer
Background Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular
aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those of …

Cholangiocarcinoma: Pathologic and molecular classification in the era of precision medicine

P Gopal, ME Robert, X Zhang - Archives of Pathology & …, 2024 - meridian.allenpress.com
Context.—Cholangiocarcinoma (CCA) is a heterogeneous cancer of the bile duct, and its
diagnosis is often challenging. Objective.—To provide insights into state-of-the-art …

Molecular tumor board as a clinical tool for converting molecular data into real-world patient care

A Vingiani, L Agnelli, M Duca, D Lorenzini… - JCO Precision …, 2023 - ascopubs.org
PURPOSE The investigation of multiple molecular targets with next-generation sequencing
(NGS) has entered clinical practice in oncology, yielding to a paradigm shift from the …

Facts and hopes in the systemic therapy of biliary tract carcinomas

A Lamarca, T Macarulla - Clinical Cancer Research, 2024 - aacrjournals.org
Biliary tract cancers (BTC) are a heterogeneous group of cancers that continue to present a
particularly poor prognosis. BTC treatment is rapidly evolving yet facing many challenges to …