Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

Abstract In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …

Objective The AMP-activated protein kinase (AMPK) gets activated in response to energetic
stress such as contractions and plays a vital role in regulating various metabolic processes …

Background Autophagy is elevated in metastatic tumors and is often associated with active
epithelial‐to‐mesenchymal transition (EMT). However, the extent to which EMT is …

Cardiovascular disease is the major cause of death worldwide. The success of medication
and other preventive measures introduced in the last century have not yet halted the …

Previous work has suggested androgen receptor (AR) signaling mediates prostate cancer
progression in part through the modulation of autophagy. However, clinical trials testing …

The calcium-calmodulin–dependent protein kinase kinase-2 (CaMKK2) is a key regulator of
cellular and whole-body energy metabolism. It is known to be activated by increases in …

CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is
linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to …

Abstract Calcium (Ca2+) ions are ubiquitous and indispensable signaling messengers that
regulate virtually every cell function. The unique ability of Ca2+ to regulate so many different …

AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1
(mTORC1) are metabolic kinases that co-ordinate nutrient supply with cell growth. AMPK …