Repetitive, monotonic, and effortful voluntary muscle contractions performed for just a few
weeks, ie, resistance training, can substantially increase maximal voluntary force in the …

Advances in medical diagnosis and treatment have facilitated the emergence of precision
medicine. In contrast, locomotor rehabilitation for individuals with acquired neuromotor …

Background. Upper-limb impairment in patients with chronic stroke appears to be partly
attributable to an upregulated reticulospinal tract (RST). Here, we assessed whether the …

Reaction time is accelerated if a loud (startling) sound accompanies the cue—the
“StartReact” effect. Animal studies revealed a reticulospinal substrate for the startle reflex; …

Early evolution of the motor cortex included development of connections to brainstem
reticulospinal neurons; these projections persist in primates. In this study, we examined the …

Humans with cervical spinal cord injury (SCI) often recover voluntary control of elbow flexors
and, to a much lesser extent, elbow extensor muscles. The neural mechanisms underlying …

Impairments in dexterous upper limb function are a significant cause of disability following
stroke. While the physiological basis of movement deficits consequent to a lesion in the …

Damage to the corticospinal and reticulospinal tract has been associated with spasticity in
humans with upper motor neuron lesions. We hypothesized that these descending motor …

Maximal rate of force development in adult humans is determined by the maximal motor unit
discharge rate, however, the origin of the underlying synaptic inputs remains unclear. Here …

Background Abnormal patterns of muscle co-activation contribute to impaired movement
after stroke. Previously, we developed a myoelectric computer interface (MyoCI) training …