Ferroptosis: molecular mechanisms and health implications

D Tang, X Chen, R Kang, G Kroemer - Cell research, 2021 - nature.com
Cell death can be executed through different subroutines. Since the description of
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …

[HTML][HTML] Impact of oxidative stress on male and female germ cells: implications for fertility

RJ Aitken - Reproduction, 2020 - rep.bioscientifica.com
Male and female germ lines are vulnerable to oxidative stress. In spermatozoa, such stress
triggers a lipid peroxidation cascade that culminates in the generation of electrophilic lipid …

Focus on ferroptosis regulation: exploring novel mechanisms and applications of ferroptosis regulator

TL Ma, JX Chen, P Zhu, CB Zhang, Y Zhou, JX Duan - Life Sciences, 2022 - Elsevier
Ferroptosis is a kind of iron-dependent regulatory necrosis characterized by the fatal
accumulation of iron-dependent lipid peroxides in the plasma membrane and the final …

Mechanisms of regulated cell death: current perspectives

SF Santagostino, CA Assenmacher… - Veterinary …, 2021 - journals.sagepub.com
Balancing cell survival and cell death is fundamental to development and homeostasis. Cell
death is regulated by multiple interconnected signaling pathways and molecular …

[HTML][HTML] Oxidative stress-induced apoptosis and autophagy: Balancing the contrary forces in spermatogenesis

P Sharma, N Kaushal, LR Saleth, S Ghavami… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Spermatogenesis is a complex process in the testis and is a cornerstone of male infertility.
The abundance of unsaturated fatty acid and high cell division rate make male germs cells …

[HTML][HTML] Exposure to low-dose cadmium induces testicular ferroptosis

L Xiong, B Zhou, JL Young, K Wintergerst… - … and environmental safety, 2022 - Elsevier
As an environmental pollutant, cadmium (Cd) has been widely reported to induce male
infertility due to its gonadotoxicity. However, the specific mechanism of Cd-induced testicular …

Effects of ferroptosis on male reproduction

Y Liu, X Cao, C He, X Guo, H Cai, A Aierken… - International journal of …, 2022 - mdpi.com
Ferroptosis is a relatively novel form of regulated cell death that was discovered in 2012.
With the increasing research related to the mechanisms of ferroptosis, previous studies have …

Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53‐ALOX15 signaling pathway

D Li, X Lu, G Xu, S Liu, Z Gong, F Lu… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Spinal cord injury (SCI) is a highly disabling condition in spinal surgery that
leads to neuronal damage and secondary inflammation. Ferroptosis is a non‐apoptotic type …

Ferroptosis: a novel type of cell death in male reproduction

Y Su, Z Liu, K Xie, Y Ren, C Li, W Chen - Genes, 2022 - mdpi.com
Ferroptosis, an iron-dependent type of regulated cell death, is triggered by the accumulation
of lethal lipid peroxides. Due to its potential in exploring disease progression and highly …

Male infertility and somatic health—insights into lipid damage as a mechanistic link

ND Burke, B Nixon, SD Roman, JE Schjenken… - Nature Reviews …, 2022 - nature.com
Over the past decade, mounting evidence has shown an alarming association between
male subfertility and poor somatic health, with substantial evidence supporting the increased …