The novel coronavirus SARS-CoV-2 enters into the human body mainly through the ACE2+
TMPRSS2+ nasal epithelial cells. The initial host response to this pathogen occurs in a …

Most existing vaccines for human use are administered by needle-based injection.
Administering vaccines needle-free intranasally has numerous advantages over by needle …

Staphylococcus aureus is an opportunistic human pathogen, which is a leading cause of
infections worldwide. The challenge in treating S. aureus infection is linked to the …

Our understanding of conventional dendritic cell (cDC) development and the functional
specializations of distinct subsets in the peripheral tissues has increased greatly in recent …

Over the past few years, nasal drug delivery has attracted more and more attentions, and
been recognized as the most promising alternative route for the systemic medication of …

The nasal administration of vaccines directed against diseases caused by upper respiratory
tract infections of pathogens, such as the influenza virus, mimics the natural infection of …

The intranasal route of vaccination presents an attractive alternative to parenteral routes and
offers numerous advantages, such as the induction of both mucosal and systemic immunity …

The olfactory organs of vertebrates are not only extraordinary chemosensory organs but also
a powerful defense system against infection. Nasopharynx-associated lymphoid tissue …

Mucosal surfaces represent important routes of entry into the human body for the majority of
pathogens, and they constitute unique sites for targeted vaccine delivery. Nanoparticle …

Introduction Our research group and others demonstrated the implication of the human
endogenous retroviruses (HERVs) in SARS-CoV-2 infection and their association with …