We aimed to identify diagnosis-specific/transdiagnostic/transoutcome multivariable
candidate predictors (MCPs) of key outcomes in mental disorders. We conducted an …

Background: In a study aimed at identifying the items carrying information regarding the
global severity of depression, the 6-item Hamilton Depression Rating Scale (HAM-D6) was …

The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

Abstract Treatment-resistant schizophrenia (TRS) will affect about one in three patients with
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …

There is no established treatment for patients with clozapine-resistant schizophrenia (CRS).
Clozapine augmentation strategies with antipsychotics or others substances are effective in …

Per Bech, one of the most influential scientists in psychological rating scales, suddenly
passed away in the spring of 2018. He was appointed Professor of Clinical Psychiatry at the …

Only about 50% of patients with treatment-resistant schizophrenia respond to clozapine, and
many more patients continue to experience ongoing and prominent negative symptoms …

Objective PANSS‐8 and PANSS‐6 are derived from the 30‐item Positive and Negative
Syndrome Scale (PANSS‐30). We investigate whether PANSS‐8 or PANSS‐6 is a reliable …

Introduction Clozapine and olanzapine are some of the most effective antipsychotics, but
both are associated with weight gain and relevant metabolic disturbances, including pre …

Severe cognitive impairments and cognitive distortions are core to schizophrenia-spectrum
disorders (SSDs) and are associated with deteriorated social functioning. Despite well …