[HTML][HTML] The quest for multiscale brain modeling
E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …
repertoire of the organ, remains challenging. In principle, it should be possible to model …
Cerebellum involvement in dystonia during associative motor learning: insights from a data-driven spiking network model
A Geminiani, A Mockevičius, E D'Angelo… - Frontiers in Systems …, 2022 - frontiersin.org
Dystonia is a movement disorder characterized by sustained or intermittent muscle
contractions causing abnormal, often repetitive movements, postures, or both. Although …
contractions causing abnormal, often repetitive movements, postures, or both. Although …
Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation
The neuroscientific field benefits from the conjoint evolution of experimental and
computational techniques, allowing for the reconstruction and simulation of complex models …
computational techniques, allowing for the reconstruction and simulation of complex models …
A realistic morpho-anatomical connection strategy for modelling full-scale point-neuron microcircuits
D Gandolfi, J Mapelli, S Solinas, R De Schepper… - Scientific Reports, 2022 - nature.com
The modeling of extended microcircuits is emerging as an effective tool to simulate the
neurophysiological correlates of brain activity and to investigate brain dysfunctions …
neurophysiological correlates of brain activity and to investigate brain dysfunctions …
Non-linear frequency dependence of neurovascular coupling in the cerebellar cortex implies vasodilation–Vasoconstriction competition
Neurovascular coupling (NVC) is the process associating local cerebral blood flow (CBF) to
neuronal activity (NA). Although NVC provides the basis for the blood oxygen level …
neuronal activity (NA). Although NVC provides the basis for the blood oxygen level …
Discovering microcircuit secrets with multi-spot imaging and electrophysiological recordings: The example of cerebellar network dynamics
The cerebellar cortex microcircuit is characterized by a highly ordered neuronal architecture
having a relatively simple and stereotyped connectivity pattern. For a long time, this …
having a relatively simple and stereotyped connectivity pattern. For a long time, this …
Bayesian Integration in a Spiking Neural System for Sensorimotor Control
The brain continuously estimates the state of body and environment, with specific regions
that are thought to act as Bayesian estimator, optimally integrating noisy and delayed …
that are thought to act as Bayesian estimator, optimally integrating noisy and delayed …
Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids
In the last decades, planar multi-electrode arrays (MEAs) have been widely used to record
activity from in vitro neuronal cell cultures and tissue slices. Though successful, this …
activity from in vitro neuronal cell cultures and tissue slices. Though successful, this …
Cerebellum involvement in dystonia: insights from a spiking neural network model during associative learning
A Geminiani, A Mockevičius, E D'Angelo… - 2022 44th Annual …, 2022 - ieeexplore.ieee.org
Dystonia is a neurological movement disorder characterized by twisting and repetitive
movements or abnormal fixed postures. This complex brain disease has usually been …
movements or abnormal fixed postures. This complex brain disease has usually been …
Cross-comparison of state of the art neuromorphological simulators on modern CPUs and GPUs using the Brain Scaffold Builder
R De Schepper, NA Akar, T Hater, BFB Huisman… - BioRxiv, 2022 - biorxiv.org
ABSTRACT A variety of software simulators exist for neuronal networks, and a subset of
these tools allow the scientist to model neurons in high morphological detail. The scalability …
these tools allow the scientist to model neurons in high morphological detail. The scalability …