Fundamentals and developments in fluorescence-guided cancer surgery

JSD Mieog, FB Achterberg, A Zlitni… - Nature reviews Clinical …, 2022 - nature.com
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …

Fluorescence-guided surgery: comprehensive review

PA Sutton, MA van Dam, RA Cahill, S Mieog… - BJS open, 2023 - academic.oup.com
Background Despite significant improvements in preoperative workup and surgical
planning, surgeons often rely on their eyes and hands during surgery. Although this can be …

A study investigating the perfusion of colorectal anastomoses using fluorescence angiography: results of the FLAG randomized trial

M Alekseev, E Rybakov, Y Shelygin… - Colorectal …, 2020 - Wiley Online Library
Aim Our aim was to evaluate the efficacy of indocyanine green (ICG) fluorescence
angiography (FA) in reducing the incidence of anastomotic leakage (AL) following colorectal …

[HTML][HTML] Blood perfusion assessment by indocyanine green fluorescence imaging for minimally invasive rectal cancer surgery (EssentiAL trial): a randomized clinical …

J Watanabe, I Takemasa, M Kotake, S Noura, K Kimura… - 2023 - journals.lww.com
Objective: The aim of the present randomized controlled trial was to evaluate the superiority
of indocyanine green fluorescence imaging (ICG-FI) in reducing the rate of anastomotic …

[HTML][HTML] Surgical treatment of low-lying rectal cancer: updates

C Varela, NK Kim - Annals of coloproctology, 2021 - ncbi.nlm.nih.gov
Despite innovative advancements, distally located rectal cancer remains a critical disease of
challenging management. The crucial location of the tumor predisposes it to a …

Impact of change in the surgical plan based on indocyanine green fluorescence angiography on the rates of colorectal anastomotic leak: a systematic review and meta …

SH Emile, SM Khan, SD Wexner - Surgical endoscopy, 2022 - Springer
Background In the present study, patients with colorectal anastomoses that were assessed
with indocyanine green (ICG) fluorescence angiography (FA) were compared to patients …

Predictive and diagnostic biomarkers of anastomotic leakage: a precision medicine approach for colorectal cancer patients

M Gray, JRK Marland, AF Murray, DJ Argyle… - Journal of personalized …, 2021 - mdpi.com
Development of an anastomotic leak (AL) following intestinal surgery for the treatment of
colorectal cancers is a life-threatening complication. Failure of the anastomosis to heal …

Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a …

RA Faber, RPJ Meijer, DHM Droogh… - The Lancet …, 2024 - thelancet.com
Background Anastomotic leakage is a severe postoperative complication in colorectal
surgery and compromised bowel perfusion is considered a major contributing factor …

Quantitative perfusion assessment using indocyanine green during surgery—current applications and recommendations for future use

P Van Den Hoven, J Osterkamp, N Nerup… - … Archives of Surgery, 2023 - Springer
Purpose Incorrect assessment of tissue perfusion carries a significant risk of complications in
surgery. The use of near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG) …

Intraoperative use of fluorescence with indocyanine green reduces anastomotic leak rates in rectal cancer surgery: an individual participant data analysis

A Arezzo, MA Bonino, F Ris, L Boni, E Cassinotti… - Surgical …, 2020 - Springer
Background Fluorescence imaging by means of Indocyanine green (ICG) has been applied
to intraoperatively determine the perfusion of the anastomosis. The purpose of this Individual …