Proteostasis refers to all the processes that maintain the correct expression level, location,
folding and turnover of proteins, essential to organismal survival. Both inside cells and in …

Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Purpose To provide a brief summary and comparison of the most recent literature on
available and theorized treatment modalities for classic lattice corneal dystrophy (LCD). This …

TGFBI-associated corneal dystrophies are inherited disorders caused by TGFBI gene
variants that promote deposition of mutant protein (TGFBIp) as insoluble aggregates in the …

The serine protease high-temperature requirement protein A1 (HtrA1) is associated with
protein-misfolding disorders such as Alzheimer's disease and transforming growth factor β …

Visual impairment and blindness is a major health burden worldwide, and major ocular
diseases causing visual impairment pertain to the anterior segment of the eye. Anterior …

We investigated the clinical and genetic features of patients with severe phenotype of
granular corneal dystrophy type 2 (GCD2) associated with compound heterozygosity in the …

More than 60 mutations in transforming growth factor beta‐induced protein (TGFBIp) have
been reported in humans causing a variety of phenotypic protein aggregates in the cornea …

Corneal stromal dystrophies are a group of genetic disorders that may be caused by
mutations in the transforming growth factor β-induced (TGFBI) gene which results in the …

Scope The purpose of this study is to identify and visualize the spatial distribution of proteins
present in amyloid corneal deposits of TGFBI‐CD patients using Mass Spectrometry Imaging …