Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Essential oils (EOs) are extracted from plants and contain active components with
therapeutic effects. Evidence shows that various types of EOs have a wide range of health …

Astrocytes contribute to brain inflammation in neurological disorders but the molecular
mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory …

Animal studies over the past two decades have led to extensive advances in our
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …

Moringa oleifera, popularly known as a miracle tree or tree of life, has been extensively used
as a functional food and nutritional asset worldwide. Ethnomedicinal and traditional uses of …

Mood disorders can be considered among the most common and debilitating mental
disorders. Major depression, as an example of mood disorders, is known to severely reduce …

In this study, we aimed to evaluate the anti-inflammatory and anti-apoptotic effects of
melatonin (MLT) on neuropathic pain (NP)-induced anxiety and depression in a rat model …

Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders.
Fetal 5-HT levels can be influenced by several gestational factors, such as maternal …

Prolonged exposure to negative stressors could be harmful if a subject cannot respond
appropriately. Strategies evolved to respond to stress, including repetitive displacement …