Cultured meat has the potential to provide a complementary meat industry with reduced
environmental, ethical, and health impacts. However, major technological challenges …

In order to meet the rising demand for biologics and become competitive on the developing
biosimilar market, there is a need for process intensification of biomanufacturing processes …

The N-linked glycosylation pattern is an important quality attribute of therapeutic
glycoproteins. It has been reported by our group and by others that different carbon sources …

Even if the performances of bioprocesses can be significantly improved by model-based
control, there often remains a tradeoff between model complexity and control robustness …

The cell culture is the central piece of a biotechnological industrial process. It includes
upstream (eg media preparation, fixed costs, etc.) and downstream steps (eg product …

In the presence of uncertainty, the optimum obtained based on a nominal identified model
can neither provide any performance guarantee nor ensure that critical constraints are …

The concept of intensified design of experiments allows a faster screening of the given
design space with the risk to introduce an irreversible impact of previous parameter settings …

Mathematical modelling can provide precious tools for bioprocess simulation, prediction,
control and optimization of mammalian cell-based cultures. In this paper we present a novel …

The structure of N-linked glycosylation is a very important quality attribute for therapeutic
monoclonal antibodies. Different carbon sources in cell culture media, such as mannose …

In biological systems, nonlinear kinetic relationships between metabolites of interest are
modeled for various purposes. Usually, little a priori knowledge is available in such models …