Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

Cancer is one of the greatest public health challenges. According to the World Health
Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most …

Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …

Triple-negative breast cancer (TNBC) is considered as the most hazardous subtype of
breast cancer owing to its accelerated progression, enormous metastatic potential, and …

Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …

Wnt signaling transduces evolutionarily conserved pathways which play important roles in
initiating and regulating a diverse range of cellular activities, including cell proliferation …

The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …

Simple Summary Breast cancer stem cells are blamed to be responsible for breast cancer
tumorigenesis, metastasis, drug resistance and tumor recurrence. Therefore, it is critical to …