Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited

X He, X Chen, Y Yang, Y Xie, Y Liu - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Epilepsy is a neurological disorder that presents with
recurring and spontaneous seizures. It is prevalent worldwide, affecting up to 65 million …

Protective effects of intranasally administrated oxytocin-loaded nanoparticles on pentylenetetrazole-kindling epilepsy in terms of seizure severity, memory …

H Sahin, O Yucel, S Emik… - ACS Chemical …, 2022 - ACS Publications
Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal
lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and …

Protective effects of lamotrigine and vitamin B12 on pentylenetetrazole-induced epileptogenesis in rats

AK Filiz, E Gumus, S Karabulut, Y Tastemur… - Epilepsy & Behavior, 2021 - Elsevier
Epileptogenesis is a process that includes molecular and cellular events that foster the
establishment of hyperexcitable neuronal networks in the brain. Pentylenetetrazole (PTZ) …

Vetiveria zizanioides modulates experimental epilepsy-induced seizures, oxidative stress, and apoptosis in the brain of rats

GP Polat, N Gumral, R Aslankoc, O Ozmen… - Metabolic Brain …, 2025 - Springer
In this study, we investigated the protective actions of Vetiveria zizanioides oil (VET) against
oxidative stress and apoptosis in a rat model of pentylenetetrazol (PTZ)-induced epilepsy …

[HTML][HTML] Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice

KS Alharbi - Brazilian Journal of Biology, 2021 - SciELO Brasil
Desvenlafaxine succinate (DVS) inhibits serotonin reuptake selectively and is approved for
major depressive disorders. This research investigated influence of DVS on modulating …

The antioxidant and neuroprotective effects of the Psychotria camptopus Verd. Hook. (Rubiaceae) stem bark methanol extract contributes to its antiepileptogenic …

AR Fokoua, AM Ajayi, B Ben-Azu, R Chouna… - Metabolic Brain …, 2021 - Springer
A substantial number of epileptic patients are resistant to the current medication thus
necessitating the search for alternative therapies for intractable forms of the disease …

Protective Effects of Artemisia persica essential oil against Pentylenetetrazol-induced seizure in male mice with emphasizing its mechanism of action

M Daneshkhah, M Setorki - Iranian Red Crescent Medical …, 2019 - search.proquest.com
Background: A new approach in the treatment of epilepsy is to use new drugs with
neuroprotective, antioxidant, and anti-inflammatory effects. Objectives: The study aimed to …

Neuroprotective efficacy of Marsilea quadrifolia leaf extract against pentylenetetrazole-induced seizure in rat model of epilepsy.

I Mohanty, M Patri - Psychology & Neuroscience, 2024 - psycnet.apa.org
Objective: The phytochemical content of leaf of Marsilea quadrifolia (MQ), an herbal
medicinal plant, has diverse medicinal properties with antiepileptic efficacy and the …

[PDF][PDF] Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats

K Yıldızhan, H Güneş… - Eastern Journal of …, 2023 - jag.journalagent.com
We aimed to examine the effects of Anakinra (AKR) and Infliximab (IFB) on increased
oxidative stress (OS) and proapoptotic pathway parameters after an epileptic attack. The rats …

[PDF][PDF] Investigation of antiepileptic potentials of usnic acid and some lichen species on the behavioral and biochemical levels in pentylenetetrazole-induced kindling …

M BERKÖZ, O YUNUSOĞLU, A ASLAN… - Journal of Research …, 2024 - avesis.yyu.edu.tr
In this study, the effects of various lichen and usnic acid applications on seizure scores and
biochemical parameters in brain tissue in rats with epilepsy model was investigated. For this …