Non-alcoholic steatohepatitis: a review of its mechanism, models and medical treatments

C Peng, AG Stewart, OL Woodman… - Frontiers in …, 2020 - frontiersin.org
Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease
(NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of …

Non-alcoholic fatty liver disease and dyslipidemia: an update

N Katsiki, DP Mikhailidis, CS Mantzoros - Metabolism, 2016 - Elsevier
Non-alcoholic fatty liver (NAFLD) is the most common liver disease worldwide, progressing
from simple steatosis to necroinflammation and fibrosis (leading to non-alcoholic …

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

QM Anstee, G Targher, CP Day - Nature reviews Gastroenterology & …, 2013 - nature.com
NAFLD is a spectrum of progressive liver disease that encompasses simple steatosis,
NASH, fibrosis and, ultimately, cirrhosis. NAFLD is recognized as the hepatic component of …

Genetic factors that affect risk of alcoholic and nonalcoholic fatty liver disease

QM Anstee, D Seth, CP Day - Gastroenterology, 2016 - Elsevier
Genome-wide association studies and candidate gene studies have informed our
understanding of factors contributing to the well-recognized interindividual variation in the …

The genetics of nonalcoholic fatty liver disease: spotlight on PNPLA3 and TM6SF2

QM Anstee, CP Day - Seminars in liver disease, 2015 - thieme-connect.com
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum that spans simple
steatosis, through nonalcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis …

Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment

P Dongiovanni, QM Anstee… - Current pharmaceutical …, 2013 - ingentaconnect.com
Liver fat deposition related to systemic insulin resistance defines non-alcoholic fatty liver
disease (NAFLD) which, when associated with oxidative hepatocellular damage …

[PDF][PDF] Genome‐Wide association study of NAFLD using electronic health records

CJ Fairfield, TM Drake, R Pius… - Hepatology …, 2022 - Wiley Online Library
Genome‐wide association studies (GWAS) have identified several risk loci for nonalcoholic
fatty liver disease (NAFLD). Previous studies have largely relied on small sample sizes and …

Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome

JB Moore - Proceedings of the Nutrition Society, 2010 - cambridge.org
Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease in both
adults and children worldwide. As a disease spectrum, NAFLD may progress from simple …

[HTML][HTML] Insulin resistance in development and progression of nonalcoholic fatty liver disease

S Alam, G Mustafa, M Alam… - World journal of …, 2016 - ncbi.nlm.nih.gov
Although insulin resistance (IR) is strongly associated with nonalcoholic fatty liver disease
(NAFLD), the association of IR and NAFLD is not universal and correlation between IR and …

[HTML][HTML] Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review

TJ Severson, S Besur, HL Bonkovsky - World journal of …, 2016 - ncbi.nlm.nih.gov
AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease
(NAFLD) onset, severity, and outcome through systematic literature review. METHODS: The …