Is enzyme immobilization a mature discipline? Some critical considerations to capitalize on the benefits of immobilization

JM Bolivar, JM Woodley… - Chemical Society …, 2022 - pubs.rsc.org
Enzyme immobilization has been developing since the 1960s and although many industrial
biocatalytic processes use the technology to improve enzyme performance, still today we …

[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Biocatalysis: enzymatic synthesis for industrial applications

S Wu, R Snajdrova, JC Moore… - Angewandte Chemie …, 2021 - Wiley Online Library
Biocatalysis has found numerous applications in various fields as an alternative to chemical
catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for …

Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

MA Huffman, A Fryszkowska, O Alvizo, M Borra-Garske… - Science, 2019 - science.org
Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing,
offering levels of selectivity and tunability that can dramatically improve chemical synthesis …

Role of biocatalysis in sustainable chemistry

RA Sheldon, JM Woodley - Chemical reviews, 2018 - ACS Publications
Based on the principles and metrics of green chemistry and sustainable development,
biocatalysis is both a green and sustainable technology. This is largely a result of the …

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades

W Finnigan, LJ Hepworth, SL Flitsch, NJ Turner - Nature catalysis, 2021 - nature.com
As the enzyme toolbox for biocatalysis has expanded, so has the potential for the
construction of powerful enzymatic cascades for efficient and selective synthesis of target …

Enzyme co-immobilization: Always the biocatalyst designers' choice… or not?

S Arana-Peña, D Carballares… - Biotechnology …, 2021 - Elsevier
The increasing relevance of cascade reactions in biocatalysis has sparked a great interest
for enzyme co-immobilization. Enzyme co-immobilization allows access to some kinetic …

The importance of synthetic chemistry in the pharmaceutical industry

KR Campos, PJ Coleman, JC Alvarez, SD Dreher… - Science, 2019 - science.org
BACKGROUND Over the past century, innovations in synthetic chemistry have greatly
enabled the discovery and development of important life-changing medicines, improving the …

Opportunities and challenges for combining chemo-and biocatalysis

F Rudroff, MD Mihovilovic, H Gröger, R Snajdrova… - Nature Catalysis, 2018 - nature.com
The past decade has seen a substantial increase in successful examples of the combination
of chemo-and biocatalysis for multistep syntheses. This is driven by obvious advantages …