Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …

With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …

Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

As essential regulators of mitochondrial quality control, mitochondrial dynamics and
mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here …

Neurons depend on autophagy to maintain cellular homeostasis, and defects in autophagy
are pathological hallmarks of neurodegenerative disease. To probe the role of basal …

Background & Aims XBP1 modulates the macrophage proinflammatory response, but its
function in macrophage stimulator of interferon genes (STING) activation and liver fibrosis is …